Lipid A as a Drug Target and Therapeutic Molecule.

ABSTRACT: In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development. Several assay methods used to screen for inhibitors of lipid A synthesis will be presented, and some of the promising lead compounds will be described. Second, utilization of lipid A biosynthetic pathways by various bacterial species can generate modified lipid A molecules with therapeutic value.

SUBMITTER: Joo SH 

PROVIDER: S-EPMC4624066 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature