DNA-Binding Kinetics Determines the Mechanism of Noise-Induced Switching in Gene Networks.

ABSTRACT: Gene regulatory networks are multistable dynamical systems in which attractor states represent cell phenotypes. Spontaneous, noise-induced transitions between these states are thought to underlie critical cellular processes, including cell developmental fate decisions, phenotypic plasticity in fluctuating environments, and carcinogenesis. As such, there is increasing interest in the development of theoretical and computational approaches that can shed light on the dynamics of these stochastic state transitions in multistable gene networks. We applied a numerical rare-event sampling algorithm to study transition paths of spontaneous noise-induced switching for a ubiquitous gene regulatory network motif, the bistable toggle switch, in which two mutually repressive genes compete for dominant

SUBMITTER: Tse MJ 

PROVIDER: S-EPMC4624158 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature