Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11.

ABSTRACT:

Background

USP4, USP15 and USP11 are paralogous deubiquitinating enzymes as evidenced by structural organization and sequence similarity. Based on known interactions and substrates it would appear that they have partially redundant roles in pathways vital to cell proliferation, development and innate immunity, and elevated expression of all three has been reported in various human malignancies. The nature and order of duplication events that gave rise to these extant genes has not been determined, nor has their functional redundancy been established experimentally at the organismal level.

Methods

We have employed phylogenetic and syntenic reconstruction methods to determine the chronology of the duplication events that generated the three paralogs and have performed genetic

SUBMITTER: Vlasschaert C 

PROVIDER: S-EPMC4624187 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature