Sensory inputs control the integration of neurogliaform interneurons into cortical circuits.

ABSTRACT: Neuronal microcircuits in the superficial layers of the mammalian cortex provide the substrate for associative cortical computation. Inhibitory interneurons constitute an essential component of the circuitry and are fundamental to the integration of local and long-range information. Here we report that, during early development, superficially positioned Reelin-expressing neurogliaform interneurons in the mouse somatosensory cortex receive afferent innervation from both cortical and thalamic excitatory sources. Attenuation of ascending sensory, but not intracortical, excitation leads to axo-dendritic morphological defects in these interneurons. Moreover, abrogation of the NMDA receptors through which the thalamic inputs signal results in a similar phenotype, as well as in the selective loss

SUBMITTER: De Marco Garcia NV 

PROVIDER: S-EPMC4624196 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature