Shared Predisposition in the Association Between Cannabis Use and Subcortical Brain Structure.

ABSTRACT:

Importance

Prior neuroimaging studies have suggested that alterations in brain structure may be a consequence of cannabis use. Siblings discordant for cannabis use offer an opportunity to use cross-sectional data to disentangle such causal hypotheses from shared effects of genetics and familial environment on brain structure and cannabis use.

Objectives

To determine whether cannabis use is associated with differences in brain structure in a large sample of twins/siblings and to examine sibling pairs discordant for cannabis use to separate potential causal and predispositional factors linking lifetime cannabis exposure to volumetric alterations.

Design, setting, and participants

Cross-sectional diagnostic interview, behavioral, and neuroimaging data were collected from

SUBMITTER: Pagliaccio D 

PROVIDER: S-EPMC4624286 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature