Cognitive resilience to apolipoprotein E ε4: contributing factors in black and white older adults.

ABSTRACT:

Importance

Apolipoprotein E (APOE) ε4 is an established risk factor for cognitive decline and the development of dementia, but other factors may help to minimize its effects.

Objective

Using APOE ε4 as an indicator of high risk, we investigated factors associated with cognitive resilience among black and white older adults who are APOE ε4 carriers.

Design, setting, and participants

Participants included 2487 community-dwelling older (aged 69-80 years at baseline) black and white adults examined at 2 community clinics in the prospective cohort Health, Aging, and Body Composition (Health ABC) study. The baseline visits occurred from May 1997 through June 1998. Our primary analytic cohort consisted of 670 APOE ε4 carriers (329 black and 341 white participants) who were f

SUBMITTER: Kaup AR 

PROVIDER: S-EPMC4624320 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature