Ontology highlight
ABSTRACT:
SUBMITTER: Galli GG
PROVIDER: S-EPMC4624327 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Molecular cell 20151001 2
The Hippo/YAP signaling pathway is a crucial regulator of tissue growth, stem cell activity, and tumorigenesis. However, the mechanism by which YAP controls transcription remains to be fully elucidated. Here, we utilize global chromatin occupancy analyses to demonstrate that robust YAP binding is restricted to a relatively small number of distal regulatory elements in the genome. YAP occupancy defines a subset of enhancers and superenhancers with the highest transcriptional outputs. YAP modulate ...[more]