Endostatin's emerging roles in angiogenesis, lymphangiogenesis, disease, and clinical applications.

ABSTRACT:

Background

Angiogenesis is the process of neovascularization from pre-existing vasculature and is involved in various physiological and pathological processes. Inhibitors of angiogenesis, administered either as individual drugs or in combination with other chemotherapy, have been shown to benefit patients with various cancers. Endostatin, a 20-kDa C-terminal fragment of type XVIII collagen, is one of the most potent inhibitors of angiogenesis.

Scope of review

We discuss the biology behind endostatin in the context of its endogenous production, the various receptors to which it binds, and the mechanisms by which it acts. We focus on its inhibitory role in angiogenesis, lymphangiogenesis, and cancer metastasis. We also present emerging clinical applications for endostatin and

SUBMITTER: Walia A 

PROVIDER: S-EPMC4624607 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature