Broad CTL Response in Early HIV Infection Drives Multiple Concurrent CTL Escapes.

ABSTRACT: Recent studies have highlighted the ability of HIV to escape from cytotoxic T lymphocyte (CTL) responses that concurrently target multiple viral epitopes. Yet, the viral dynamics involved in such escape are incompletely understood. Previous analyses have made several strong assumptions regarding HIV escape from CTL responses such as independent or non-concurrent escape from individual CTL responses. Using experimental data from evolution of HIV half genomes in four patients we observe concurrent viral escape from multiple CTL responses during early infection (first 100 days of infection), providing confirmation of a recent result found in a study of one HIV-infected patient. We show that current methods of estimating CTL escape rates, based on the assumption of independent escapes, are bia

SUBMITTER: Leviyang S 

PROVIDER: S-EPMC4624722 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature