Transcriptional Profile of Bacillus subtilis sigF-Mutant during Vegetative Growth.

ABSTRACT: Sigma factor F is the first forespore specific transcription factor in Bacillus subtilis and controls genes required for the early stages of prespore development. The role of sigF is well studied under conditions that induce sporulation. Here, the impact of sigF disruption on the transcriptome of exponentially growing cultures is studied by micro-array analysis. Under these conditions that typically don't induce sporulation, the transcriptome showed minor signs of sporulation initiation. The number of genes differentially expressed and the magnitude of expression were, as expected, quite small in comparison with sporulation conditions. The genes mildly down-regulated were mostly involved in anabolism and the genes mildly up-regulated, in particular fatty acid degradation genes, were mostly

SUBMITTER: Overkamp W 

PROVIDER: S-EPMC4624776 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature