Bone Morphogenetic Protein for the Healing of Tibial Fracture: A Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Purpose

To review the evidence from RCTs on clinical outcomes and benefit of acute tibial fracture and nonunion treated with and without BMPs.

Material

We searched multiple databases (MEDLINE, EMABSE, BIOSIS and Cochrane central) as well as reference lists of articles and contacted authors. Evaluated outcomes included union rate, revision rate, hardware failure and infection. The weighted and standard mean difference (WMD and SMD) or the relative risk (RR) was calculated for continuous or dichotomous data respectively. The quality of the trial was assessed, and meta-analyses were performed with the Cochrane Collaboration's REVMAN 5.0 software.

Results

Eight RCTs involving 1113 patients were included. For acute tibial fracture, BMP group was associated with a higher ra

SUBMITTER: Dai J 

PROVIDER: S-EPMC4624800 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature