Ontology highlight
ABSTRACT:
SUBMITTER: Hofmann JW
PROVIDER: S-EPMC4624921 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Cell 20150122 3
MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. In contrast, we find that Myc haploinsufficient (Myc(+/-)) mice exhibit increased lifespan. They show resistance to several age-associated pathologies, including osteoporosis, cardiac fibrosis, and immunosenescence. They also appear to be more active, with a higher metabolic rate and healthier lipid metabolism. Transcriptomic analysis reveals a gene expression signature enriched for metabolic and immune processe ...[more]