Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis.

ABSTRACT: Enzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in Saccharopolyspora erythraea , the mutagenesis of DEBS and bioanalytical data on the experimental investigation of studies on the biosynthetic pathway towards erythromycin are presented.

SUBMITTER: Klopries S 

PROVIDER: S-EPMC4625040 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature