High efficacy vasopermeability drug candidates identified by screening in an ex ovo chorioallantoic membrane model.

ABSTRACT: The use of rodent models to evaluate efficacy during testing is accompanied by significant economic and regulatory hurdles which compound the costs of screening for promising drug candidates. Vasopermeation Enhancement Agents (VEAs) are a new class of biologics that are designed to increase the uptake of cancer therapeutics at the tumor site by modifying vascular permeability in the tumor to increase the therapeutic index of co-administered drugs. To evaluate the efficacy of a panel of VEA clinical candidates, we compared the rodent Miles assay to an equivalent assay in the ex ovo chicken embryo model. Both model systems identified the same candidate (PVL 10) as the most active promoter of vasopermeation in non-tumor tissues. An ex ovo chicken embryo system was utilized to test each candid

SUBMITTER: Pink D 

PROVIDER: S-EPMC4625159 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature