Tourniquet induced ischemia and changes in metabolism during TKA: a randomized study using microdialysis.

ABSTRACT:

Background

Tourniquet use in total knee arthroplasty (TKA) surgery is applied to minimize blood loss thereby creating better overview of the surgical field. This induces ischemia in the skeletal muscle resulting in reperfusion injury. Our aim was to investigate the in vivo metabolic changes in the skeletal muscle during TKA surgery using microdialysis (MD).

Methods

Seventy patients were randomly allocated to tourniquet group (n = 35) or non-tourniquet group (n = 35). Prior to surgery, catheters were inserted in the operated leg and non-operated leg. Interstitial dialysate was collected before and after surgery and at 20 min intervals during a 5 h reperfusion period. Main variables were ischemic metabolites: glucose, pyruvate, lactate and glycerol and L/P ratio.

Results

SUBMITTER: Ejaz A 

PROVIDER: S-EPMC4625433 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature