Methodological standardization for the pre-clinical evaluation of renal sympathetic denervation.

ABSTRACT: Transcatheter ablation of renal autonomic nerves is a viable option for the treatment of resistant arterial hypertension; however, structured pre-clinical evaluation with standardization of analytical procedures remains a clear gap in this field. Here we discuss the topics relevant to the pre-clinical model for the evaluation of renal denervation (RDN) devices and report methodologies and criteria toward standardization of the safety and efficacy assessment, including histopathological evaluations of the renal artery, periarterial nerves, and associated periadventitial tissues. The pre-clinical swine renal artery model can be used effectively to assess both the safety and efficacy of RDN technologies. Assessment of the efficacy of RDN modalities primarily focuses on the determination of th

SUBMITTER: Sakakura K 

PROVIDER: S-EPMC4625553 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature