Hierarchical nesting of slow oscillations, spindles and ripples in the human hippocampus during sleep.

ABSTRACT: During systems-level consolidation, mnemonic representations initially reliant on the hippocampus are thought to migrate to neocortical sites for more permanent storage, with an eminent role of sleep for facilitating this information transfer. Mechanistically, consolidation processes have been hypothesized to rely on systematic interactions between the three cardinal neuronal oscillations characterizing non-rapid eye movement (NREM) sleep. Under global control of de- and hyperpolarizing slow oscillations (SOs), sleep spindles may cluster hippocampal ripples for a precisely timed transfer of local information to the neocortex. We used direct intracranial electroencephalogram recordings from human epilepsy patients during natural sleep to test the assumption that SOs, spindles and ripples ar

SUBMITTER: Staresina BP 

PROVIDER: S-EPMC4625581 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature