Enhanced artemisinin yield by expression of rol genes in Artemisia annua.

ABSTRACT:

Background

Despite of many advances in the treatment of malaria, it is still the fifth most prevalent disease worldwide and is one of the major causes of death in the developing countries which accounted for 584,000 deaths in 2013, as estimated by World Health Organization. Artemisinin from Artemisia annua is still one of the most effective treatments for malaria. Increasing the artemisinin content of A. annua plants by genetic engineering would improve the availability of this much-needed drug.

Methods

In this regard, a high artemisinin-yielding hybrid of A. annua produced by the centre for novel agricultural products of the University of York, UK, was selected (artemisinin maximally 1.4 %). As rol genes are potential candidates of biochemical engineering, genetic transform

SUBMITTER: Dilshad E 

PROVIDER: S-EPMC4625606 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature