Mesoderm-specific transcript (MEST) is a negative regulator of human adipocyte differentiation.

ABSTRACT:

Background

A growing body of evidence suggests that many downstream pathologies of obesity are amplified or even initiated by molecular changes within the white adipose tissue (WAT). Such changes are the result of an excessive expansion of individual white adipocytes and could potentially be ameliorated via an increase in de novo adipocyte recruitment (adipogenesis). Mesoderm-specific transcript (MEST) is a protein with a putative yet unidentified enzymatic function and has previously been shown to correlate with adiposity and adipocyte size in mouse.

Objectives

This study analysed WAT samples and employed a cell model of adipogenesis to characterise MEST expression and function in human.

Methods and results

MEST mRNA and protein levels increased during adipocyte diff

SUBMITTER: Karbiener M 

PROVIDER: S-EPMC4625608 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature