The HAND Database: a gateway to understanding the role of HIV in HIV-associated neurocognitive disorders.

ABSTRACT:

Background

Despite an augmented research effort and scale-up of highly active antiretroviral therapy, a high prevalence of HIV-1-associated neurocognitive disorders (HAND) persists in the HIV-infected population. Nearly 50 % of all HIV-1-infected individuals suffer from a neurocognitive disorder due to neural and synaptodendritic damage. Challenges in HAND research, including limited availability of brain tissue from HIV patients, variation in HAND study protocols, and virus genotyping inconsistency and errors, however, have resulted in studies with insufficient power to delineate molecular mechanisms underlying HAND pathogenesis. There exists, therefore, a great need for a reliable and centralized resource specific to HAND research, particularly for epidemiological study and surve

SUBMITTER: Griffin TZ 

PROVIDER: S-EPMC4625622 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature