Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial.

ABSTRACT:

Background

Severe malaria remains a major cause of childhood mortality globally. Decreased endothelial nitric oxide is associated with severe and fatal malaria. The hypothesis was that adjunctive inhaled nitric oxide (iNO) would improve outcomes in African children with severe malaria.

Methods

A randomized, blinded, placebo-controlled trial of iNO at 80 ppm by non-rebreather mask versus room air placebo as adjunctive treatment to artesunate in children with severe malaria was conducted. The primary outcome was the longitudinal course of angiopoietin-2 (Ang-2), an endothelial biomarker of malaria severity and clinical outcome.

Results

One hundred and eighty children were enrolled; 88 were assigned to iNO and 92 to placebo (all received IV artesunate). Ang-2 levels meas

SUBMITTER: Hawkes MT 

PROVIDER: S-EPMC4625637 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature