Blood transcriptomics of drug-naive sporadic Parkinson's disease patients.

ABSTRACT:

Background

Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder that is clinically defined in terms of motor symptoms. These are preceded by prodromal non-motor manifestations that prove the systemic nature of the disease. Identifying genes and pathways altered in living patients provide new information on the diagnosis and pathogenesis of sporadic PD.

Methods

Changes in gene expression in the blood of 40 sporadic PD patients and 20 healthy controls ("Discovery set") were analyzed by taking advantage of the Affymetrix platform. Patients were at the onset of motor symptoms and before initiating any pharmacological treatment. Data analysis was performed by applying Ranking-Principal Component Analysis, PUMA and Significance Analysis of Microarrays. Func

SUBMITTER: Calligaris R 

PROVIDER: S-EPMC4625854 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature