Immunotherapy for neuro-oncology: the critical rationale for combinatorial therapy.

ABSTRACT: A successful therapeutic paradigm established historically in oncology involves combining agents with potentially complementary mechanisms of antitumor activity into rationally designed regimens. For example, cocktails of cytotoxic agents, which were carefully designed based on mechanisms of action, dose, and scheduling considerations, have led to dramatic improvements in survival including cures for childhood leukemia, Hodgkin's lymphoma, and several other complex cancers. Outcome for glioblastoma, the most common primary malignant CNS cancer, has been more modest, but nonetheless our current standard of care derives from confirmation that combination therapy surpasses single modality therapy. Immunotherapy has recently come of age for medical oncology with exciting therapeutic benefits a

SUBMITTER: Reardon DA 

PROVIDER: S-EPMC4625894 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature