Integrated analysis of differential gene expression profiles in hippocampi to identify candidate genes involved in Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is a complex neurodegenerative disorder with largely unknown genetic mechanisms. Identifying altered neuronal gene expression in AD may provide diagnostic or therapeutic targets for AD. The present study aimed to identify differentially expressed genes (DEGs) and their further association with other biological processes that regulate causative factors for AD. The present study performed an integrated analysis of publicly available gene expression omnibus datasets of AD hippocampi. Gene ontology (GO) enrichment analyses, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and Protein‑Protein interaction (PPI) network analysis were performed. The present study detected 295 DEGs (109 upregulated and 186 downregulated genes) in hippocampi between AD and con

SUBMITTER: Hu W 

PROVIDER: S-EPMC4626122 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature