Interaction between years of education and APOE ε4 status on frontal and temporal metabolism.

ABSTRACT:

Objective

To examine interactions between years of education and APOE ε4 status on gray matter volume and metabolism in cognitively healthy participants.

Methods

Seventy-two healthy participants (28 APOE ε4 carriers and 44 noncarriers; from 23 to 84 years of age) with FDG-PET and structural MRI were included. A subgroup also underwent florbetapir-PET. We tested the interaction effect between years of education and APOE ε4 status (carrier vs noncarrier) on FDG-PET and structural MRI within the whole brain (voxel-wise) adjusting for age and sex. Computed florbetapir standardized uptake value ratios were used for complementary analyses.

Results

We found an interaction between years of education and APOE ε4 status on frontotemporal FDG-PET metabolism, such that higher edu

SUBMITTER: Arenaza-Urquijo EM 

PROVIDER: S-EPMC4626241 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature