Association of systemic lupus erythematosus with decreased immunosuppressive potential of the IgG glycome.

ABSTRACT:

Objective

Glycans attached to the Fc portion of IgG are important modulators of IgG effector functions. Interindividual differences in IgG glycome composition are large and they associate strongly with different inflammatory and autoimmune diseases. IKZF1, HLA-DQ2A/B, and BACH2 genetic loci that affect IgG glycome composition show pleiotropy with systemic lupus erythematosus (SLE), indicating a potentially causative role of aberrant IgG glycosylation in SLE. We undertook this large multicenter case-control study to determine whether SLE is associated with altered IgG glycosylation.

Methods

Using ultra-performance liquid chromatography analysis of released glycans, we analyzed the composition of the IgG glycome in 261 SLE patients and 247 matched controls of Latin American Me

SUBMITTER: Vuckovic F 

PROVIDER: S-EPMC4626261 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature