The role of the non-covalent β-ionone-ring binding site in rhodopsin: historical and physiological perspective.

ABSTRACT: Bleached rhodopsin regenerates by way of the Schiff base formation between the 11-cis retinal and opsin. Recovery of human vision from light adapted states follows biphasic kinetics and each adaptive phase is assigned to two distinct classes of visual pigments in cones and rods, respectively, suggesting that the speed of Schiff base formation differs between iodopsin and rhodopsin. Matsumoto and Yoshizawa predicted the existence of a β-ionone ring-binding site in rhodopsin, which has been proven by structural studies. They postulated that rhodopsin regeneration starts with a non-covalent binding of the β-ionone ring moiety of 11-cis-retinal, followed by the Schiff base formation. Recent physiological investigation revealed that non-covalent occupation of the β-ionone ring binding site tran

SUBMITTER: Matsumoto H 

PROVIDER: S-EPMC4626282 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature