A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery.

ABSTRACT:

Background

Transfusion-related acute lung injury incidence remains the leading cause of posttransfusion mortality. The etiology may be related to leukocyte antibodies or biologically active compounds in transfused plasma, injuring susceptible recipient's lungs. The authors have hypothesized that transfusion could have less severe effects that are not always appreciated clinically and have shown subtly decreased pulmonary oxygen gas transfer in healthy volunteers after transfusion of fresh and 21-day stored erythrocytes. In this study, the authors tested the same hypothesis in surgical patients.

Methods

Ninety-one patients undergoing elective major spine surgery with anticipated need for erythrocyte transfusion were randomly allocated to receive their first transfusion of ery

SUBMITTER: Feiner JR 

PROVIDER: S-EPMC4626309 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature