(18)F-Alfatide II PET/CT in healthy human volunteers and patients with brain metastases.

ABSTRACT:

Purpose

We report the biodistribution and radiation dosimetry of an integrin αvβ3 specific PET tracer (18)F-AlF-NOTA-E[PEG4-c(RGDfk)]2) (denoted as (18)F-Alfatide II). We also assessed the value of (18)F-Alfatide II in patients with brain metastases.

Methods

A series of torso (from the skull to the thigh) static images were acquired in five healthy volunteers (3 M, 2 F) at 5, 10, 15, 30, 45, and 60 min after injection of (18)F-Alfatide II (257 ± 48 MBq). Regions of interest (ROIs) were drawn manually, and the time-activity curves (TACs) were obtained for major organs. Nine patients with brain metastases were examined by static PET imaging with (18)F-FDG (5.55 MBq/kg) and (18)F-Alfatide II.

Results

Injection of (18)F-Alfatide II was well tolerated in all healthy volunt

SUBMITTER: Yu C 

PROVIDER: S-EPMC4626365 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature