Ontology highlight
ABSTRACT:
SUBMITTER: Stieglitz E
PROVIDER: S-EPMC4626387 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Nature genetics 20151012 11
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of childhood with a poor prognosis. Mutations in NF1, NRAS, KRAS, PTPN11 or CBL occur in 85% of patients, yet there are currently no risk stratification algorithms capable of predicting which patients will be refractory to conventional treatment and could therefore be candidates for experimental therapies. In addition, few molecular pathways aside from the RAS-MAPK pathway have been identified that could serve as the ...[more]