WASP: allele-specific software for robust molecular quantitative trait locus discovery.

ABSTRACT: Allele-specific sequencing reads provide a powerful signal for identifying molecular quantitative trait loci (QTLs), but they are challenging to analyze and are prone to technical artifacts. Here we describe WASP, a suite of tools for unbiased allele-specific read mapping and discovery of molecular QTLs. Using simulated reads, RNA-seq reads and chromatin immunoprecipitation sequencing (ChIP-seq) reads, we demonstrate that WASP has a low error rate and is far more powerful than existing QTL-mapping approaches.

SUBMITTER: van de Geijn B 

PROVIDER: S-EPMC4626402 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature