Macrophage polarization in cattle experimentally exposed to Mycobacterium avium subsp. paratuberculosis.

ABSTRACT: Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of Johne's disease (JD) in cattle, has significant impacts on the livestock industry and has been implicated in the etiology of Crohn's disease. Macrophages play a key role in JD pathogenesis, which is driven by the manipulation of host immune mechanisms by MAP. A change in the macrophage microenvironment due to pathogenic or host-derived stimuli can lead to classical (M1) or alternative (M2) polarization of macrophages. In addition, prior exposure to antigenic stimuli has been reported to alter the response of macrophages to subsequent stimuli. However, macrophage polarization in response to MAP exposure and its possible implications have not been previously addressed. In this study, we have comprehensively examine

SUBMITTER: Thirunavukkarasu S 

PROVIDER: S-EPMC4626599 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature