Nephroprotection by Hypoglycemic Agents: Do We Have Supporting Data?

ABSTRACT: Current therapy directed at delaying the progression of diabetic nephropathy includes intensive glycemic and optimal blood pressure control, renin angiotensin-aldosterone system blockade and multifactorial intervention. However, the renal protection provided by these therapeutic modalities is incomplete. There is a scarcity of studies analysing the nephroprotective effect of antihyperglycaemic drugs beyond their glucose lowering effect and improved glycaemic control on the prevention and progression of diabetic nephropathy. This article analyzes the exisiting data about older and newer drugs as well as the mechanisms associated with hypoglycemic drugs, apart from their well known blood glucose lowering effect, in the prevention and progression of diabetic nephropathy. Most of them have bee

SUBMITTER: Gorriz JL 

PROVIDER: S-EPMC4626660 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature