Rapid, Multiplexed Phosphoprotein Profiling Using Silicon Photonic Sensor Arrays.

ABSTRACT: Extracellular signaling is commonly mediated through post-translational protein modifications that propagate messages from membrane-bound receptors to ultimately regulate gene expression. Signaling cascades are ubiquitously intertwined, and a full understanding of function can only be gleaned by observing dynamics across multiple key signaling nodes. Importantly, targets within signaling cascades often represent opportunities for therapeutic development or can serve as diagnostic biomarkers. Protein phosphorylation is a particularly important post-translational modification that controls many essential cellular signaling pathways. Not surprisingly, aberrant phosphorylation is found in many human diseases, including cancer, and phosphoprotein-based biomarker signatures hold unrealized promi

SUBMITTER: Wade JH 

PROVIDER: S-EPMC4626792 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature