Dengue virus infection alters post-transcriptional modification of microRNAs in the mosquito vector Aedes aegypti.

ABSTRACT: Recent discoveries regarding the importance of isomiRs have increased our understanding of the regulatory complexities of the miRNAome. Observed changes in the miRNA profiles in mosquitoes infected with flaviviruses have implicated small RNAs in the interactions between viruses and their vectors. Here we analysed the isomiR profiles of both uninfected and infected Aedes aegypti mosquitoes with the major human pathogen dengue virus (DENV). We found that several specific isomiRs were significantly altered in their abundance patterns in response to DENV infection potentially affecting their target repertoire. Notable among these were isomiR variants which displayed arm-switching. We also demonstrate that modifications to the 3p end of miRNAs are vastly more prevalent than those at the 5p ends

SUBMITTER: Etebari K 

PROVIDER: S-EPMC4626843 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature