Neuroprotective Effects of Voluntary Exercise in an Inherited Retinal Degeneration Mouse Model.

ABSTRACT:

Purpose

Our previous investigations showed that involuntary treadmill exercise is neuroprotective in a light-induced retinal degeneration mouse model, and it may act through activation of tropomyosin-related kinase B (TrkB) receptors. This study investigated whether voluntary running wheel exercise can be neuroprotective in an inheritable model of the retinal degenerative disease retinitis pigmentosa (RP), rd10 mice.

Methods

Breeding pairs of rd10 and C57BL/6J mice were given free-spinning (active) or locked (inactive) running wheels. Pups were weaned into separate cages with their parents' respective wheel types, and visual function was tested with ERG and a virtual optokinetic system at 4, 5, and 6 weeks of age. Offspring were killed at 6 weeks of age and retinal cross-sec

SUBMITTER: Hanif AM 

PROVIDER: S-EPMC4627249 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature