A detailed view of the intracellular transcriptome of Listeria monocytogenes in murine macrophages using RNA-seq.

ABSTRACT: Listeria monocytogenes is a bacterial pathogen and causative agent for the foodborne infection listeriosis, which is mainly a threat for pregnant, elderly, or immunocompromised individuals. Due to its ability to invade and colonize diverse eukaryotic cell types including cells from invertebrates, L. monocytogenes has become a well-established model organism for intracellular growth. Almost 10 years ago, we and others presented the first whole-genome microarray-based intracellular transcriptome of L. monocytogenes. With the advent of newer technologies addressing transcriptomes in greater detail, we revisit this work, and analyze the intracellular transcriptome of L. monocytogenes during growth in murine macrophages using a deep sequencing based approach. We detected 656 differentially expr

SUBMITTER: Schultze T 

PROVIDER: S-EPMC4627465 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature