Regulation of dendrimer/dextran material performance by altered tissue microenvironment in inflammation and neoplasia.

ABSTRACT: A "one material fits all" mindset ignores profound differences in target tissues that affect their responses and reactivity. Yet little attention has been paid to the role of diseased tissue on material performance, biocompatibility, and healing capacity. We assessed material-tissue interactions with a prototypical adhesive material based on dendrimer/dextran and colon as a model tissue platform. Adhesive materials have high sensitivity to changes in their environment and can be exploited to probe and quantify the influence of even subtle modifications in tissue architecture and biology. We studied inflammatory colitis and colon cancer and found not only a difference in adhesion related to surface chemical interactions but also the existence of a complex interplay that determined the overa

SUBMITTER: Oliva N 

PROVIDER: S-EPMC4627493 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature