Association Study of Genotype by Depressive Response during Tryptophan Depletion in Subjects Recovered from Major Depression.

ABSTRACT:

Purpose

The brief and reversible mood response to acute tryptophan (TRP) depletion (ATD) is being studied as a trait marker in subjects considered at risk for major depression (MD).

Procedures

ATD was administered to 64 subjects (54 European-Americans, and10 from other races) with personal and family history of MD. They were in remission and had been medication-free for at least three months. Subjects received an active and sham condition in a random assignment, double-blind crossover design. They were genotyped for serotonin-related candidate genes, and mood response was quantified with the Hamilton Depression Rating Scale (HDRS). Data were analyzed using Poisson regression with repeated measures and latent trajectory models.

Results

Compared to the sham control, act

SUBMITTER: Moreno FA 

PROVIDER: S-EPMC4627710 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature