A Scale-Corrected Comparison of Linkage Disequilibrium Levels between Genic and Non-Genic Regions.

ABSTRACT: The understanding of non-random association between loci, termed linkage disequilibrium (LD), plays a central role in genomic research. Since causal mutations are generally not included in genomic marker data, LD between those and available markers is essential for capturing the effects of causal loci on localizing genes responsible for traits. Thus, the interpretation of association studies requires a detailed knowledge of LD patterns. It is well known that most LD measures depend on minor allele frequencies (MAF) of the considered loci and the magnitude of LD is influenced by the physical distances between loci. In the present study, a procedure to compare the LD structure between genomic regions comprising several markers each is suggested. The approach accounts for different scaling fa

SUBMITTER: Berger S 

PROVIDER: S-EPMC4627745 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature