Oxygen-Driven Tumour Growth Model: A Pathology-Relevant Mathematical Approach.

ABSTRACT: Xenografts--as simplified animal models of cancer-differ substantially in vasculature and stromal architecture when compared to clinical tumours. This makes mathematical model-based predictions of clinical outcome challenging. Our objective is to further understand differences in tumour progression and physiology between animal models and the clinic. To achieve that, we propose a mathematical model based upon tumour pathophysiology, where oxygen--as a surrogate for endocrine delivery--is our main focus. The Oxygen-Driven Model (ODM), using oxygen diffusion equations, describes tumour growth, hypoxia and necrosis. The ODM describes two key physiological parameters. Apparent oxygen uptake rate (k'R) represents the amount of oxygen cells seem to need to proliferate. The more oxygen they appea

SUBMITTER: Delgado-SanMartin JA 

PROVIDER: S-EPMC4627780 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature