Reproducibility and Temporal Structure in Weekly Resting-State fMRI over a Period of 3.5 Years.

ABSTRACT: Resting-state functional MRI (rs-fMRI) permits study of the brain's functional networks without requiring participants to perform tasks. Robust changes in such resting state networks (RSNs) have been observed in neurologic disorders, and rs-fMRI outcome measures are candidate biomarkers for monitoring clinical trials, including trials of extended therapeutic interventions for rehabilitation of patients with chronic conditions. In this study, we aim to present a unique longitudinal dataset reporting on a healthy adult subject scanned weekly over 3.5 years and identify rs-fMRI outcome measures appropriate for clinical trials. Accordingly, we assessed the reproducibility, and characterized the temporal structure of, rs-fMRI outcome measures derived using independent component analysis (ICA).

SUBMITTER: Choe AS 

PROVIDER: S-EPMC4627782 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature