IL-4/10 prevents stress vulnerability following imipramine discontinuation.

ABSTRACT:

Background

Identifying stress vulnerability after antidepressant discontinuation may be useful in treating relapses in depression. Previous studies have suggested significant effects of the immune system as well as the central nervous system (CNS) on progression and induction of major depression. In the present study, we hypothesized that the factors that are not rescued by a tricyclic antidepressant imipramine may be associated with stress vulnerability and relapses in depression.

Methods

To address this issue, mice were exposed to 2 h of restraint stress for 21 consecutive days (chronic restraint stress (CRS)) with or without co-treatment of imipramine. These groups were exposed to an electronic foot shock (FS) as additional stress after imipramine washout. Main targets of

SUBMITTER: Han A 

PROVIDER: S-EPMC4628271 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature