A broad scope knowledge based model for optimization of VMAT in esophageal cancer: validation and assessment of plan quality among different treatment centers.

ABSTRACT:

Background

To evaluate the performance of a broad scope model-based optimisation process for volumetric modulated arc therapy applied to esophageal cancer.

Methods and materials

A set of 70 previously treated patients in two different institutions, were selected to train a model for the prediction of dose-volume constraints. The model was built with a broad-scope purpose, aiming to be effective for different dose prescriptions and tumour localisations. It was validated on three groups of patients from the same institution and from another clinic not providing patients for the training phase. Comparison of the automated plans was done against reference cases given by the clinically accepted plans.

Results

Quantitative improvements (statistically significant for the maj

SUBMITTER: Fogliata A 

PROVIDER: S-EPMC4628288 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature