Treatment of early non-response in patients with schizophrenia: assessing the efficacy of antipsychotic dose escalation.

ABSTRACT:

Background

Early non-response to antipsychotic treatment in patients with schizophrenia has been shown in multiple studies to predict poor response at short-term trial endpoint. Therefore, strategies to address the challenge of non-improvement early in the course of treatment are needed. A novel trial design was developed to assess the potential utility of antipsychotic dose escalation in patients with an inadequate initial treatment response. This design was embedded in a study intended to assess the efficacy of low dose lurasidone in patients with schizophrenia. The purpose of this report is to describe the background, rationale and design of this study that included a novel method for the assessment of the potential for dose-response in early non-responding patients with schizop

SUBMITTER: Loebel A 

PROVIDER: S-EPMC4628370 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature