PTEN expression in benign human endometrial tissue and cancer in relation to endometrial cancer risk factors.

ABSTRACT:

Purpose

Clonal loss of PTEN expression occurs frequently in endometrial carcinoma and endometrial hyperplasia. Limited data from immunohistochemical studies suggest that PTEN-null appearing endometrial glands are detectable in women without pathologic abnormalities, but the relationship of PTEN expression to endometrial cancer risk factors has not been extensively explored. We evaluated relationships between endometrial cancer risk factors and loss of PTEN expression in a set of benign endometrial samples prospectively collected from women undergoing hysterectomy and in endometrial cancer tissues from a population-based case-control study.

Methods

We used a validated PTEN immunohistochemical assay to assess expression in epidemiological studies designed to assess benign endo

SUBMITTER: Yang HP 

PROVIDER: S-EPMC4628559 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature