MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Context

Head and neck squamous cell carcinoma (HNSCC) is a highly invasive cancer with an association with locoregional recurrence and lymph node metastasis. We have previously reported that low microRNA-375 (miR-375) expression levels correlate with poor patient survival, increased locoregional recurrence, and distant metastasis. Increasing miR-375 expression in HNSCC cell lines to levels found in normal cells results in suppressed invasive properties. HNSCC invasion is mediated in part by invadopodia-associated degradation of the extracellular matrix.

Objective

To determine whether elevated miR-375 expression in HNSCC cell lines also affects invadopodia formation and activity.

Design

For evaluation of the matrix degradation properties of the HNSCC lines, an invadopo

SUBMITTER: Jimenez L 

PROVIDER: S-EPMC4628565 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature