Synergistic Effects of Combined Cell Therapy for Chronic Ischemic Cardiomyopathy.

ABSTRACT:

Background

Both bone marrow-derived mesenchymal stem cells (MSCs) and c-kit(+) cardiac stem cells (CSCs) improve left ventricular remodeling in porcine models and clinical trials. Using xenogeneic (human) cells in immunosuppressed animals with acute ischemic heart disease, we previously showed that these 2 cell types act synergistically.

Objectives

To more accurately model clinical applications for heart failure, this study tested whether the combination of autologous MSCs and CSCs produce greater improvement in cardiac performance than MSCs alone in a nonimmunosuppressed porcine model of chronic ischemic cardiomyopathy.

Methods

Three months after ischemia/reperfusion injury, Göttingen swine received transendocardial injections with MSCs alone (n = 6) or in combinatio

SUBMITTER: Karantalis V 

PROVIDER: S-EPMC4628729 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature