Immunogenetics of systemic lupus erythematosus: A comprehensive review.

ABSTRACT: Our understanding of the genetic basis of systemic lupus erythematosus has progressed rapidly in recent years. While many genetic polymorphisms have been associated with disease susceptibility, the next major step involves integrating these genetic polymorphisms into the molecular mechanisms and cellular immunology of the human disease. In this review, we summarize some recent work in this area, including the genetics of the type I IFN response in SLE, including polygenic and monogenic factors, as well as epigenetic influences. Contributions of both HLA and non-HLA polymorphisms to the complex genetics of SLE are reviewed. We also review recent reports of specific gene deficits leading to monogenic SLE-like syndromes. The molecular functions of common SLE-risk variants are reviewed in dept

SUBMITTER: Ghodke-Puranik Y 

PROVIDER: S-EPMC4628859 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature