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Benzophenone and its analogs bind to human glyoxalase 1.

ABSTRACT: Benzophenone is a popular photophore for photoaffinity-labeling. It is also an important framework for drug development; many drugs contain benzophenone or analogous frameworks. The current work reports that benzophenone and its analogs bind to human glyoxalase 1. The binding, however, has little effect on the catalytic activity of this enzyme. The implications of the finding in terms of both drug development and photoaffinity-labeling are discussed.

SUBMITTER: Mihai DM

PROVIDER: S-EPMC4628877 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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Benzophenone and its analogs bind to human glyoxalase 1.

Mihai Doina M DM Hall Steven S Deng Haiteng H Welch Christopher J CJ Kawamura Akira A

Bioorganic & medicinal chemistry letters 20150915 22

Benzophenone is a popular photophore for photoaffinity-labeling. It is also an important framework for drug development; many drugs contain benzophenone or analogous frameworks. The current work reports that benzophenone and its analogs bind to human glyoxalase 1. The binding, however, has little effect on the catalytic activity of this enzyme. The implications of the finding in terms of both drug development and photoaffinity-labeling are discussed. ...[more]

PMID: 26420066

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